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The effects of auto-brewery syndrome

The effects of auto-brewery syndrome


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Why are some people affected so differently by auto-brewery syndrome differently if the syndrome seems to be caused by the single organism saccharomyces cerevisiae? It is known that the syndrome has been used to waive DUI charges - like most recently for this New Yorker whose blood alcohol level was 0.4 but she had none of the usual symptoms of intoxication, even though she had ingested alcohol earlier that day. She also carried out most of her daily activities normally, even with high levels of alcohol in her system.

On the other hand, there was another case where the carrier experience the effects of auto-brewery syndrome differently:

Cases involving the yeast Candida albicans and Candida krusei have popped up in Japan, and in 2013 Panola College Dean of Nursing Barbara Cordell documented the case of a 61-year-old man who had frequent bouts of unexplained drunkenness for years before being diagnosed with an overabundance of Saccharomyces cerevisiae, or brewer's yeast, the same yeast used to make beer.

The quote can also be found at the link of the CNN article.

Could the difference in symptoms and effects due to variations in how the carrier bodies could deal with the overabundance (maybe depending on age, gender, or ethnicity) or are they attributed to variations in the nature of the yeast?


The gut microbiome is extremely complicated, and almost anything related to it is only partially known, therefore prone to oversimplification. Trying to explain the phenomenon of gut fermentation syndrome in such a limited fashion (age, gender, ethnicity, quantity of one particular yeast, etc.) will not help us understand it.

Common yeasts (C. albicans, C. tropicalis and Torulopsis glabrata) and Saccharomyces cerevisiae are able to ferment sugars through the homolactic, heterolactic or mixed acid fermentation pathways, with ethanol as the major end product.

Candida is a very common yeast found in the environment and in and on our bodies wherever it's warm and moist (therefore the GI tract.) Candida species are the most common cause of invasive fungal infections in humans (followed by Cryptococcus and Aspergillus) and can involve any organ. Yet it's omnipresence does not result in clinically recognized cases of ethanol intoxication in even a minute fraction of people who carry it in their gut.

Case reports started appearing in the literature starting in 1972, yet it is still a rare event to see one. In 2001, the case of a 13 year old girl was published. She had short gut syndrome and became intoxicated after ingesting carbohydrates. She had been placed in a rehabilitation facility with no access to alcohol, but still had positive blood alcohols. Aspirates from her small intestines grew Candida glabrata and Saccharomyces cerevisiae. Short-gut syndrome is complicated.

We have no idea how common fermentation into alcohol is in the gut, or what the results are, but it is probably far more common than recognized, can probably result in effects other than intoxication (for example fatty liver disease in non-drinkers), and probably has a role in other illnesses. It's complicated:

Carbohydrate metabolism by gut microorganisms is a central process allowing supply of nutrients and energy to the host. This fermentative process is complex and involves several functional groups of bacteria with complementary metabolic activities that interact to ensure the biotransformation of polymers (resistant starch, nonstarch polysaccharides, proteins, mucins… ) into end-products (mainly short chain fatty acids and gases). Hydrolytic communities transform complex substrates into smaller fragments that can also be used by other bacterial groups unable to hydrolyse polymers. Other microbial cross-feeding interactions are related to the utilisation of fermentative products such as succinate, lactate or hydrogen and involve specific groups of microorganisms.

All we know is that it happens in some people, and that it can respond to antifungal treatment and some probiotic supplementation. "Why" is still a mystery, and speculation only.

Gut fermentation syndrome
Invasive Fungal Pathogens: Current Epidemiological Trends
IwataK., “A Review of the Literature on Drunken Syndromes Due to Yeasts in the Gastrointestinal Tract,” University of Tokyo Press, Tokyo, 1972, 260-268. Not available online
Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome
Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis


Auto-Brewery Syndrome (ABS): Causes, Symptoms, Risk Factors, Diagnosis And Treatment

Auto-brewery syndrome (ABS), also known as 'gut fermentation syndrome' is a rare disease in which a special type of yeast called Saccharomyces cerevisiae and others outgrow in the gut and converts carbohydrates into ethanol, giving symptoms of alcohol intoxication to an individual without even its consumption. This disease was first diagnosed in the 1970s in Japan. Only a few cases of ABS have been reported in the past three decades [1] .

According to a report published on 5 August 2019 in the journal BMJ Open Gastroenterology, a 46-year-old man was diagnosed with this uncommon medical condition. Medical experts say that the patient was a healthy and active man and had no previous medical condition. In the year 2011, he got an antibiotic therapy due to his thumb injury. Later, he started experiencing episodes of depression, personality change and drunkenness (without having alcohol).

Then on one morning, he was arrested for 'drunk and drive' and the police refused to believe him. After proper investigation and diagnosis, it was found that he had a rare auto-brewery syndrome in which his intestine itself was producing alcohol after fermenting the carbohydrates he was consuming [4] .


Case history

A previously active, healthy, 46-year-old man (height, 6 feet 2 inches weight, 230 lbs body mass index, 30 kg/m 2 ) with no significant medical or psychiatric history sought our help for the confirmation and treatment of ABS. He was not taking any medications, including herbal or over-the-counter drugs. He complained of having had memory loss, mental changes, and episodes of depression for over 6 years starting in January of 2011. These changes started to occur after he received antibiotic therapy (cephalexin 250 mg orally three times a day for 3 weeks) for a complicated traumatic thumb injury. One week after the completion of his antibiotic therapy, personality changes with episodes of depression, ‘brain fog’, and aggressive behaviour became apparent, which was very uncharacteristic for him. He was initially evaluated by his primary care physician (PCP) for the first time in January of 2014 before being referred to a psychiatrist who treated him with lorazepam and fluoxetine.

One morning, he was arrested for presumed driving while intoxicated (DWI). He refused a breathalyser analysis and was hospitalised. His initial blood alcohol level was 200 mg/dL. The hospital personnel and police refused to believe him when he repeatedly denied alcohol ingestion. He recovered fully and was discharged.

After hearing about a similar successfully treated case by a physician in Ohio, his aunt purchased a breathalyser to record his breath alcohol levels and persuaded him to visit Ohio for the treatment, where basic laboratory testing (complete blood count, comprehensive metabolic panel, immunology panel, and urinalysis) were all normal. A comprehensive stool analysis was negative for Giardia and Cryptosporidium. The patient’s lactoferrin, calprotectin, and lysozyme levels and stool malabsorption studies were also normal. Saccharomyces cerevisiae (brewer’s yeast) and S. boulardii were detected in his stool addition to his normal stool bacterial flora. On antifungal sensitivity testing, these Saccharomyces strains were found to be sensitive to azoles and nystatin.

To confirm the diagnosis of ABS, the patient was given a carbohydrate meal, and his blood alcohol levels were monitored under observation. After 8 hours, his blood alcohol level was elevated to 57 mg/dL. He was then treated for the Saccharomyces fungi found in his stool with oral fluconazole 150 mg per day for 14 days. In the absence of improvement, on day 10, this was changed to nystatin 500 000 IU three times a day for another 10 days. His symptoms improved, and he was discharged on a strict carbohydrate-free diet along with special supplements given by his Ohio physician, but no further antifungal therapy was prescribed.

After a few weeks of being asymptomatic, intermittent ‘flares’ returned. He was seen by many internists, psychiatrists, neurologists, and gastroenterologists who were unable to help him to return to his previous state of health. The most significant event caused by one of his inebriations was a fall that caused intracranial bleeding and necessitated a transfer to a regional neurosurgical centre, where he had a complete spontaneous recovery in 10 days. In this institution, his blood alcohol levels ranged from 50 to 400 mg/dL. Here too, the medical staff refused to believe that he did not drink alcohol despite his persistent denials.

Due to worsening symptoms, he searched for help from an online support group and contacted us. This patient physical examination was entirely normal. Prior to his thumb injury, he had been a light social drinker but completely abstained from alcohol thereafter. His construction company was involved in restoring hurricane-damaged houses, many of which had mould contamination. To investigate this patient’s condition further, we collected gastrointestinal secretions using upper and lower endoscopy to detect fungi. The patient’s upper and lower endoscopic procedures were normal. Fungal cultures obtained from the upper small gut and cecal secretions grew Candida albicans and C. parapsilosis. Antifungal sensitivity testing was done for these fungi, and both were sensitive to azoles. His secretory immunoglobulin A was elevated to 607 mg/dL. Helicobacter pylori infection was not detected in his gastric antral biopsy. The patient agreed to be treated in collaboration with his local PCP because he lived far away from our hospital.

Given his prior exposure to fluconazole, we decided to use oral itraconazole 150 mg per day as an initial antifungal therapy for S. cerevisiae and Candida species. After 10 days, as his symptoms did not improve, so this dose was increased to 200 mg per day, and the patient became completely asymptomatic. Unbeknownst to us, he ate pizza and drank soda while on this treatment, resulting in a severe ABS relapse. We then decided to treat him with intravenous micafungin 150 mg per day for 6 weeks.

After completing this therapy, his gastrointestinal secretions were again studied and cultured by repeat upper and lower endoscopy. At this time, no fungal growth was present. The patient monitored his breath alcohol levels two times a day throughout the treatment process with instructions to inform us immediately if positive. He was started on a probiotic (single-strain Lactobacillus acidophilus with 3 billion colony-forming units per capsule) to competitively inhibit fungi and help to normalise his gut flora.2 Carbohydrates were then gradually introduced in his diet, and a repeat carbohydrate challenge test was negative. After 6 weeks, this probiotic was changed to a multi-strain probiotic, which contains 12 different bacterial organisms without any fungi.3 4 He has since continued this treatment. Approximately 1.5 years later, he remains asymptomatic and has resumed his previous lifestyle, including eating a normal diet while still checking his breath alcohol levels sporadically. A summarise format of the time course of events and interventions is presented in table 1.


Auto-Brewery Syndrome: Apparently, You Can Make Beer In Your Gut

Most of us prefer drinking fermented beverages,€” not producing them in our gut.

This medical case may give a whole new meaning to the phrase "beer gut."

A 61-year-old man — with a history of home-brewing — stumbled into a Texas emergency room complaining of dizziness. Nurses ran a Breathalyzer test. And sure enough, the man's blood alcohol concentration was a whopping 0.37 percent, or almost five times the legal limit for driving in Texas.

There was just one hitch: The man said that he hadn't touched a drop of alcohol that day.

"He would get drunk out of the blue — on a Sunday morning after being at church, or really, just anytime," says Barabara Cordell, the dean of nursing at Panola College in Carthage, Texas. "His wife was so dismayed about it that she even bought a Breathalyzer."

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Other medical professionals chalked up the man's problem to "closet drinking." But Cordell and Dr. Justin McCarthy, a gastroenterologist in Lubbock, wanted to figure out what was really going on.

So the team searched the man's belongings for liquor and then isolated him in a hospital room for 24 hours. Throughout the day, he ate carbohydrate-rich foods, and the doctors periodically checked his blood for alcohol. At one point, it rose 0.12 percent.

Eventually, McCarthy and Cordell pinpointed the culprit: an overabundance of brewer's yeast in his gut.

That's right, folks. According to Cordell and McCarthy, the man's intestinal tract was acting like his own internal brewery.

The patient had an infection with Saccharomyces cerevisiae, Cordell says. So when he ate or drank a bunch of starch — a bagel, pasta or even a soda — the yeast fermented the sugars into ethanol, and he would get drunk. Essentially, he was brewing beer in his own gut. Cordell and McCarthy reported the case of "auto-brewery syndrome" a few months ago in the International Journal of Clinical Medicine.

When we first read the case study, we were more than a little skeptical. It sounded crazy, a phenomenon akin to spontaneous combustion. I mean, come on: Could a person's gut really generate that much ethanol?

Brewer's yeast is in a whole host of foods, including breads, wine and, of course, beer (hence, the name). The critters usually don't do any harm. They just flow right through us. Some people even take Saccharomyces as a probiotic supplement.

But it turns out that in rare cases, the yeasty beasts can indeed take up long-term residency in the gut and possibly cause problems, says Dr. Joseph Heitman, a microbiologist at Duke University.

"Researchers have shown unequivocally that Saccharomyces can grow in the intestinal tract," Heitman tells The Salt. "But it's still unclear whether it's associated with any disease" — or whether it could make someone drunk from the gut up.

We dug around the scant literature on auto-brewery syndrome and uncovered a handful of cases similar to the one in Texas. Some reports in Japan date back to the 1970s. In most instances, the infections occurred after a person took antibiotics — which can wipe out the bacteria in the gut, making room for fungi like yeast to flourish — or had another illness that suppresses their immune system.

Still, such case reports remain extremely rare. Heitman says he had never heard of auto-brewery syndrome until we called him up. "It sounds interesting," he says. But he's also cautious.

"The problem with a case report," he notes, "is that it's just one person. It's not a controlled clinical study."


Auto-Brewery Syndrome: How This Man Could Brew Alcohol In His Gut

This could be taking the concept of home brewing a bit further than you’d like. The medical journal BMJ Open Gastroenterology included a case report about a man who brewed his own alcohol. But you probably wouldn’t have wanted to take a sip of it.

That’s because it was a case of auto-brewery syndrome (ABS), otherwise known as gut fermentation syndrome. If you are wondering, oh poop, where is the alcohol being brewed, you’d be right. This is a situation in which fungal yeast grows in the intestines, in this case the small intestines and the cecum. Where is the cecum, which is pronounced “seek-um”? Well, if you seek-um yeast that’s in the cecum, you’ll find em in a pouch where the small and large intestines meet. That yeast then may ferment carbohydrates into alcohol.

Feeling inebriated after you've drunk alcohol is one thing. But what happened if you feel drunk when . [+] you haven't had anything? (Photo: Getty Images)

It took a while for the 46-year-old man featured in the case report to realize that something was literally brewing in his guts. The trouble began after he had gotten a three-week course of the antibiotic cephalexin for a bad thumb injury. A week after completing these antibiotics, he began experiencing personality changes, including depression, “brain fog”, and aggressive behavior. He even ended receiving anti-depressant medications to treat these new symptoms. Later on, he was arrested for a presumed DWI (driving while intoxicated) even though he had denied ever drinking any alcohol. During the subsequent hospitalization, testing found his blood alcohol level to be 200 mg/dL. Pretty high for not having imbibed any alcohol.

Eventually his aunt persuaded him to use a breathalyzer to record his alcohol levels and visit a doctor in Ohio who had treated what sounded like a similar case. It turned out that his DWI had been due to his driving with intestines or driving with something in his intestines. The something was Saccharomyces cerevisiae, also known as brewer’s yeast and S. boulardii. The doctor gave him a carbohydrate meal and followed his blood alcohol levels, finding that they reached 57 mg/dL after eight hours. At yeast, the doctor had found the culprit. The man apparently had ABS.


Auto Brewery Syndrome : Drunk without Drinking

You won't believe this fact that a person can show symptoms of of drunk man, even without drinking. Even all of his alcohol tests will come positive. Such situation is common if one is suffering from Auto Brewery Syndrome. However this medical condition is very rare. Some people who know this medical condition try to use it as a defense against drunk-driving charges. Here we will explain more about this "Drunk without drinking" Auto Brewery Syndrome.

Auto Brewery Syndrome

Auto Brewery Syndrome is a medical condition in which fermentation of carbohydrates occur in our digestive system and creates alcohol. A person suffering from this condition can easily feel drunk after few hours of carbohydrate rich diet. Auto Brewery Syndrome is also known as Gut fermentation syndrome. There is not much documentation available about this disease.

In 2013 Journal of Scientific Research published a report about 61 year old man who had this syndrome from past 20 years. His blood alcohol level was found 0.40 without drinking. According to him this condition started after he had irritable bowel syndrome that worsened to bloating and gas. Later muscular pain, headache and mood disturbances became a part of his life.
In some extreme cases Auto-brewery syndrome can cause alcohol or methanol poisoning which may lead to death.

Social effects of Auto Brewery Syndrome

  • It reduces the working capicity of person and affects his job and personal life.
  • It can demotivate a person to a great extent.
  • The friend circle of the person is reduced is very much and most of the people feel that he/she is drunk. Such person feel alone and detached from family and friends.

Cause of Auto Brewery Syndrome

This condition occurs as a result of too much yeast trapped in digestive system. That yeast can ferment any carbohydrate into ethanol.


Treating Auto-Brewery Syndrome

Once you have a diagnosis of ABS, the treatment may not be simple or straightforward. Your primary provider may decide to try anti-fungal medications but some patients respond to medication and other do not. Some patients take long courses or several courses of the medication before seeing results and there are side effect to most of the medications and they can be hard on your liver.

Whether of not you decide to take medications, almost all patients must abstain from alcohol and maintain a low glycemic index diet at least until symptoms subside and the stool culture comes back negative for yeast. Many patients decide to maintain the diet long term in order to prevent a relapse.

Environmental triggers are important to identify in addition to food that provokes symptoms, because ABS may be brought on by mold in your house, yeast and mold exposure at work, such as exposure to soil, moldy substances, or damp locations.

It’s important to read up on the treatment of yeast overgrowth as many physicians are not aware of the severe symptoms that can occur in patients with overgrowth.

My 57yr old husband has been dealing with this syndrome for approximately18 months. What test is recommended to determine the level of causative yeast? We have determined it takes his body 24-36 hours to produce the symptoms after ingesting any carbohydrates.

I took a fecal test to determine the yeast in my stool

Hi,
I believe my husband has this. We are getting passed from doctor to doctor. They did a stool sample but then told us that they weren’t able to test for yeast this way. I feel that is wrong. Anyone else have a stool sample performed with an analysis done for yeast?

They can test for yeast through a stool sample. It’s not a culture but a DNA test and is done by many labs, Quest Diagnostics being one.

He should eat more sauerkraut and drink kombucha. It will cure him. There is a dysbiosis in his guts.

There is a section on the blog called Diagnosing ABS that has more information.

For the last month and a half I have had this drunk feeling and headaches and I have been given anti biotics, steroids, and had an MRi of my brain with more blood work and another MRI for my neck. When I read this article it really hit home because I have diabetes 2 and cant control my sugar levels. I try and eat right but I do eat some carbs and yeast products. Please send me any other information or who I could call to find out more about this. Thank you

I’m posting everything I know on this website. Best wishes

I have ABS and it is miserable! Now that I have completely changed my diet I feel great. You CAN feel better! I would be happy to share my story and what I have learned through trial and error.

It’s good to know you have managed your symptoms. However, there are many people who have not responded to dietary changes alone and require medications.

Hi Paul Whitwell, I have ABS too and it is terrible. I would like to know your story a everything about your diet. Thanks
Dana

I would love to hear your story and how you are doing, the changes you made or supplements you took for abs. boyfriend is struggling with this and we identifued it about 6 weeks ago. fatty liver, seizures etc… wakes up at a .17 on average. trying low carb, no fermented foods, no dairy and no starches etc… added probiotics a few days ago. doctors are not on board yet. :/

My husband has rhis condition butcwe can’t find anyone to treat it. We live un Michigan about 90 miles from Chicago. Any suggestions?

My wife and I have been unknowingly dealing with this issue for many years, but she was eventually diagnosed with ABS about 20 months ago. She has been treating with mixed results. Unfortunately, it appears that she is becoming more sensitive to other triggers, including mold, pet dander, and even alcohol-based body lotions that she was using for dry skin. We recently performed a very controlled study by getting baseline breathalyzer numbers, eliminating food and other triggers and applying her normal body lotion and found that about 30-40 minutes afterwards her BAC was about .08.
We replicated this test three consecutive days with similar results. We have changed all body care and cosmetics to eliminate any alcohol related products with some success. This does not address all the other major triggers. Of course, despite living a major city with many medical schools, we have not been able to find someone who knows or understands the syndrome. Any suggestion or comments would be appreciated.

Anyone with this, or thinks they have this needs to get a "comprehensive digestive stool analysis" or CDSA for short, done. Level 3 or higher. Usually from a "functional" pathology lab. It’s not just your standard stool test, they will explain.

If it shows saccharomyces cerevisiae, a bakers or brewers yeast. Chances are you have youself abs.

Comes with MANY gastrointestinal issues. You’re not just simply drunk

Be aware that there are a number of fermenting organisms in addition to S. cerevisiae that seem to contribute to this disorder.


Auto-brewery Syndrome in the Setting of Long-standing Crohn's Disease: A Case Report and Review of the Literature

Clinical background: A 71-year-old male with 50-year history of Crohn's disease was evaluated for acute onset of dizziness and slurred speech. Blood ethanol levels were elevated despite abstinence from alcohol for over 30 years. CT enterography demonstrated massive dilation of the small bowel with anastomotic stricture.

Discussion: Auto-brewery syndrome may be considered in a patient with chronic obstruction or hypomotility presenting with elevated serum ethanol levels in the setting of high carbohydrate intake. Although treatment algorithms lack validation, judicious use of antibiotic therapy, carbohydrate control, and short courses of antifungal therapy have all been reported in the literature. Importantly, clinical consideration of 'auto-brewery' should be undertaken with substantial caution, given the lack of validated mechanisms linking endogenous ethanol production to peripheral blood ethanol.


The Terrifying Disease that Turns Your Body into a Brewery

A 61-year-old man staggers into an emergency room complaining of dizziness. When nurses check his blood alcohol content (BAC), they discover that he’s incredibly drunk — at 0.37 percent, he’s almost five times over the legal limit to drive in most states. “But that can’t be right,” the man says, “I haven’t had a drop of alcohol all day.”

After taking antibiotics for a traumatic t humb injury, a 46-year-old man begins noticing an uncharacteristic depression and a “brain fog.” One morning, he is stopped and arrested on suspicion of drunken driving. Though he swears he hasn’t consumed any alcohol, he registers a BAC of 0.2, over twice the legal limit. Police and hospital staff don’t believe him when he asserts that he hasn’t been drinking.

A 61-year-old woman diagnosed with cirrhosis, a late stage of liver damage and scarring, arrives at the hospital for her liver transplant but is denied when testing finds alcohol in her urine. Doctors suspect her of alcohol abuse. But to the confusion of the hospital staff, she continues to insists that she is completely sober.

As it turns out, each of these people were telling the truth they hadn’t ingested any alcohol. They had, however, produced alcohol within their own gut. They were all later diagnosed with a rare, little-studied, and “underdiagnosed” medical condition called auto-brewery syndrome. According to researchers, auto-brewery syndrome is “a condition in which ethanol is produced through endogenous fermentation by fungi or bacteria in the gastrointestinal (GI) system.” Put simply, if a certain kind of yeast infects your gastrointestinal system, that yeast can ferment the carbohydrates you eat into alcohol, which will enter the bloodstream and cause chronic extreme blood alcohol levels.

The yeast in question here is called Saccharomyces cerevisiae, also known as “brewer’s yeast.” Saccharomyces has been used for thousands of years to make bread, wine, and, of course, beer, but most of the time it goes right through the human body without any trouble. Occasionally, however, scientists have discovered, Saccharomyces can take up firm residence in the gastrointestinal system and begin fermenting any carbohydrates the patient eats into significant levels of alcohol, enough not only to make patients chronically and unexpectedly inebriated but also to produce all of the medical implications of serious alcoholism.

What causes auto-brewery syndrome? Well, scientists believe that patients gastrointestinal issues like diabetes, obesity, or Crohn’s disease may be particularly at-risk, but in healthy individuals the most common cause is a significant change in the gastrointestinal microbiome, such as over-exposure to antibiotics. In other words, according to the British medical journal Open Gastroenterology, seriously altering the gut’s bacterial balance with antibiotics may leave an opening for Saccharomyces to gain a stronghold in the GI system. As for recovery, research has shown that “in single and various combinations, dietary carbohydrate control, antifungal or antibiotic therapy, general antibiotic avoidance, and probiotics have all been reported as successful treatments.”

For one 34-year-old British man, however, neither antifungal treatments nor probiotics nor special supplements have been effective in relieving his auto-brewery syndrome. After 20 years of chronic dizziness, nausea, “hangover symptoms,” and even aggression, Matthew Hogg finally discovered the cause, auto-brewery syndrome, after “reading a book about a Japanese man who was arrested by police for drunk-driving despite insisting he was teetotal.”

Unable to hold down a job and pursue a career as a nutritional therapist, Hogg says he must also adhere to a strict carb-free diet to manage the production of alcohol by the yeast in his gut. “Every time I eat bread, potatoes or starchy rice I produce 100% proof drinking alcohol that travels around my body through my bloodstream,” says Hogg, “if I eat a portion of rice I would suffer a hangover equivalent of having glugged three bottles of red wine the night before.”

The effects of Hogg’s auto-brewery syndrome became particularly problematic after high school. “I would start feeling intoxicated a few hours after having something to eat as my body began digesting it,” he says. “I’m usually quite a shy and quiet person and had a lot of friends at school, but there were times when I would act like a raging drunk by saying horrible things to people, slurring words, upsetting people and just stirring up trouble.”

Sure, at first glance, auto-brewery syndrome sounds sort of silly and fun. Wouldn’t it be funny to suddenly feel intoxicated at work? But thinking about the larger implications, such as the possibility of alcohol poisoning, the uncontrollable and near-constant drunkenness, or the inability to maintain consistent focus or mood, puts a the disease in sobering perspective.

“It’s a horrible illness,” says Barbara Cordell, a researcher of auto-brewery syndrome and the author of “My Gut Makes Alcohol.” For six years her husband suffered from auto-brewery syndrome before they discovered the reason he often slurred his words and lost coordination. If he ate a carb-heavy meal, she said, he would soon show signs of intoxication. “I think there are a lot more people suffering than we even know,” says Cordell, who now runs a support group for about 200 people with auto-brewery syndrome.

Some, however, have cast doubt on the idea that auto-brewery syndrome is a real disease. One such study, published in Science and Justice, claimed that despite the fact that auto-brewery syndrome had been used effectively as a defense for alcohol-related crimes, “none of the studies published supporting the theory have withstood close scrutiny.” In particular, auto-brewery syndrome has been a successful legal defense for drunk driving. In 2014, the driver of a truck that spilled 11,000 salmon onto a highway claimed to have auto-brewery syndrome. The following year, a woman had her drunk driving charges dismissed after her legal representatives provided evidence that she had auto-brewery syndrome.

While auto-brewery syndrome still needs to be studied more fully, one thing is for sure: the idea of producing your own alcohol is no laughing matter.


Auto-brewery syndrome

Saccharomyces cerevisiae is a yeast identified as the pathogen that causes auto-brewery syndrome.I am message box. Click edit button to change this text.

Auto-brewery syndrome or gut fermentation syndrome is a condition in which ethanol is produced through endogenous fermentation in the gastrointestinal (GI) system.

Spontaneous ethanol production occurs via a different metabolic pathway. Auto-brewery syndrome occurs in patients with alcohol intoxication after they ingest carbohydrate-rich meals.

Auto-brewery syndrome has significant effects on life. The patient may experience side effects of belching, chronic fatigue syndrome, dizziness, dry mouth, disorientation, hangovers, and irritable bowel syndrome.

The chronic fatigue syndrome can result in health problems such as anxiety, depression, and poor productivity. The random state of intoxication can result in difficulties, and the obscurity of the condition may make it difficult to diagnose and find a successful treatment.

The treatment of auto-brewery syndrome is a modification in the diet requiring high protein and low carbohydrates.
Sugar is fermented into alcohol, a diet that lowers sugars will decrease the alcohol fermented from the gastrointestinal tract. Anything that causes an imbalance between harmful and beneficial bacteria can potentially increase fermentation in the gut. This may include antibiotics and the overindulgence in sugars and carbohydrates.


Watch the video: Οι επιπτώσεις του Ανθρώπου στο Περιβάλλον. The effects of human actions on the environment. (October 2022).